In medicine, the full form of ALT is Alanine Transaminase. When the liver or heart is damaged, an enzyme known as ALT is released into the bloodstream. This enzyme is normally found in the cells of the liver and heart. The levels of ALT in the blood are raised when there is liver damage (such as from viral hepatitis) or an injury to the heart (such as from a heart attack). ALT levels can also be increased by some medications. SGPT (Serum Glutamic Pyruvic Transaminase) is another name for ALT. This test can be used by a doctor to determine whether a drug, disease or injury has harmed your liver.
The liver is responsible for many essential functions, including; It removes waste products and other toxins from your blood, producing proteins and cholesterol, and it produces a fluid called bile that aids in food digestion. The liver can be damaged by cirrhosis and hepatitis, which prevents it from performing its numerous essential functions. If you exhibit any of the signs and symptoms of liver disease or damage, such as stomach pain or swelling, nausea, vomiting, yellow skin or eyes (jaundice), weakness, extreme tiredness, dark urine, light poop, or itchy skin are all symptoms of this condition.
The amount of alanine transaminase (ALT) in your blood is determined by a blood test. Since ALT levels in the blood can rise when your liver is damaged, healthcare professionals frequently use an ALT blood test to assess your liver's health.
Healthcare providers do not rely solely on the ALT test to diagnose conditions because ALT levels can rise in response to a variety of liver conditions. A blood test panel, such as a liver enzyme panel (HFP or LFT) or a comprehensive metabolic panel (CMP), typically includes an ALT blood test. A blood panel can provide more in-depth information about your overall health by measuring multiple aspects of your blood with a single sample.
The evaluation of your liver's health is the goal of an ALT blood test. An ALT blood test can help identify liver issues if damaged cells in your liver cause ALT to leak into your blood. A blood panel test that includes an ALT test may be ordered by your doctor to check for, monitor, or diagnose liver conditions.
In a health screening, potential problems are checked for before symptoms appear. If you have any of the following risk factors for liver disease, your healthcare provider will probably recommend screening with a liver panel blood test that includes an ALT test:
Heavy drinking.
A family history of liver disease.
Diabetes.
Obesity.
Using shared needles to inject drugs.
You may undergo an ALT test even if you do not have risk factors for liver disease because ALT tests are frequently included in routine blood panel tests that assess your general overall health, such as a comprehensive metabolic panel (CMP).
If you have a liver condition, your doctor may order an ALT test, usually as part of a panel, to see if your condition is getting better, getting worse, or staying the same whether you take medication or not. If you are taking a medication that can have an effect on your liver health, your doctor may also order an ALT test and a liver enzyme panel test for you.
If you show signs and symptoms of potential liver problems, your doctor may use an ALT test to diagnose you. Even though ALT levels alone cannot diagnose a condition, they can be an important component of the process.
Conditions of the liver can cause the following symptoms:
Vomiting and/or nausea.
Pain in the abdomen
Skin that itches
Jaundice (a condition in which your skin and eyes become yellow)
Fatigue
Loss of appetite
Usually, a liver function test will measure ALT/ (Aspartate transaminase)AST levels. This is a straightforward blood test that can be performed at your healthcare provider's office, a laboratory, or a hospital.
Getting Ready for the Test
Prior to the blood draw, this test typically requires a period of fasting. As a result, you will be asked to avoid eating for a period of 12 hours prior to your arrival. Before the test, ask your doctor if you need to stop taking any of your medications.
Throughout the Test
You will be required to roll up your sleeves to show your elbow bend. After cleaning the area, your doctor or nurse will fasten a bandage to your arm above your elbow. To make it easier for you to locate the vein, you will be asked to make a fist.
When the needle is inserted, there might be a pinch. After the sample has been taken, your doctor or nurse will cover the area with gauze.
After the Test
After the test, you might experience lightheadedness right away. If so, don't try to drive home until you feel better.
Where your blood was drawn, you might have some minor bruising. For a few days, the area may feel sore.
A high level of the enzyme AST (aspartate aminotransferase) can point to liver issues. However, this typically does not indicate that you require medical attention. It very well may be a symptom of a drug. Pancreatitis, hepatitis, cirrhosis, mononucleosis, heart problems, and very high AST levels are all possible diagnoses.
For AST, 48 IU(International Units)/L(Litre) is the normal limit; levels that are twice or three times the normal limit are considered mildly elevated. AST levels can be 50 times higher than normal in liver disease. This is referred to as deranged levels in medicine.
By altering their diet and engaging in regular physical activity, individuals can lower their ALT levels. Lowering levels may be aided by increasing fiber intake, reducing processed foods and saturated fats, and consuming a variety of nutrients from fruits and vegetables.
After vigorous exercise, ALT and AST can remain elevated for seven or more days. Higher peak levels and levels remaining high for a longer period of time are correlated with workout duration and intensity. When compared to athletes with more training, untrained athletes will experience longer and larger increases.
ALT levels can fluctuate by 45 percent in a single day, peaking in the afternoon and falling at night.