Amoebiasis - Overview, Symptoms, causes

Amoebiasis - Overview, Symptoms, causes

Edited By Irshad Anwar | Updated on Oct 04, 2024 04:06 PM IST

Amoebiasis is also termed as amoebic dysentery. It is usually caused by a protozoan that is named Entamoeba histolytica. They normally live inside the human's large intestine and help produce eggs which then pass out with the stool and result in diarrhoea. It is transmitted in areas where there is poor sanitation which allows the contamination of drinking water and food with the stool of the people. It is most common in some of the Indian continents and also in parts of Central and South America. Amoebiasis is one of the important biology topic from the chapter Health and Diseases CBSE class 12th. It has a weightage of around 1-2% of the total marks in the exams like NEET, Paramedical and Pharmacy.

People who are at risk of Amoebiasis

Amoebiasis is caused by several reasons, some of the major ones discussed below. There are certain conditions which allow the parasite to grow itself and spread the Amoebiasis disease.

  • Travelers of tropical regions.

  • People who come from areas that have poor sanitary conditions.

  • People who are living in developing areas lack clean water and proper sanitation infrastructure.

  • Healthcare workers who are exposed to infected patients or contaminated environments.

  • Food handlers who are in contact with contaminated food especially in underdeveloped areas.

  • People engaged in oral-anal sexual practices with the infected person.

  • People who have weak immune systems and are prone to other diseases also have a high risk of Amoebiasis.

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Pathway of Amoebiasis in the Human Body

This disease is generally caused by a protozoan named Entamoeba histolytica.

Pathways

Explanation

Mode of entry

  • Ingestion of Cysts happens through contaminated water and food.

  • Majorly it is due to direct contact with fecal matter.

The inactive form of the cysts

  • The cysts are capable of surviving in the soil or harsh environment for months.

  • This is because this parasite is in an inactive form.

Parasite activation

  • Cysts once enter into the digestive tract and release Trophozoites the parasites are activated.

  • Now this active parasite usually reproduces inside the digestive tract and then migrates to the large intestine.

  • Now these organisms burrow in the large intestine and cause the disease.


Transmission via food handlers

  • This is one of the most common ways of spreading the cysts of Entamoeba histolytica.

  • The cysts spread while preparing food in unhygienic places.

Contaminated sources

  • The major sources of contamination are soil fertilizers and contaminated food with infected faeces.

Sexual transmission

  • A major possibility of transmission also happens when one is involved in activities like oral anal or anal sex with the infected person.


Life Cycle of Entamoeba Histolytica ( Amoebiasis)

The life cycle of Entamoeba histolytica is described below which will give you a better understanding of how it grows inside the human body.

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Symptoms of Amoebiasis

Symptoms of Amoebiasis are often confused with different diseases. Some of the major symptoms and their explanations are given below:

Symptoms

Explanation Of The Symptoms

Asymptotic Infection

  • This is the most common symptom among the patients.

  • No visible symptoms in the infected person.


Acute Amoebiasis

  • Diarrhea or dysentery with blood in the stools.

  • The stools are more frequent than the normal.

Chronic Amoebiasis

  • The symptoms include signs like pus in the stools, weight loss, fever and fatigue.

Intestinal Symptoms

  • Symptoms are generally visible after 1 to 4 weeks of ingestion of Cysts.

  • Loose stools, Stomach Cramps, Abdominal pain, and bloating are some of the common signs.

Fulminant Colitis

  • Inflammation in the colon leads to abdominal pain bloody diarrhoea and in the worst cases perforation of the intestines.

Peritonitis

  • Major inflammation is seen in the abdominal lining due to intestine perforation.

  • This also causes severe abdominal pain fever and in some cases, there is a possibility of life-threatening infection.


Liver Abscess

  • Continuous fever and pain in the upper right quadrant of the abdomen.

  • There is also a sensation of tenderness in the region.

  • Occurs only if the parasite has infected the liver which leads to abscess formation.

Cardiac and Cerebral Symptoms

  • In rare cases, the parasite affects the heart or brain which leads to serious complications.

  • Often treated by surgeries.

Respiratory symptoms

  • The parasite enters the main bloodstream and damages the lungs and heart.

  • This also leads to difficulty in breathing.

Other complications

  • Amoebic ulcers are common when we talk about infection in the intestine.

  • When the parasite affects the main bloodstream it also leads to anemia due to the blood loss.

  • Continuous diarrhoea will push the body to a dehydration state.




Diagnosis of Amoebiasis

Infection of Amoebiasis can occur in several parts of the body. This is the only reason why several tests and diagnosis methods are used to get accurate treatment. Some of the major ones are described below:

Diagnosis Methods

Diagnosis Explanation

Stool test

  • A stool sample is tested for the presence of E. histolytica

  • The presence of the parasite confirms Amoebiasis.

Enzyme-linked Immunosorbent Assay ( ELISA)

  • There is detection of antigen for antibodies present in the stool. This confirms the Amoebiasis.

Enzyme Immunoassay (EIA)

  • There is testing for extra-intestinal Amoebiasis.

  • This is not a stool-based test.

Indirect Hemagglutination (IHA)

  • Antibodies are detected in patients' blood.

  • If the antibodies are absent the test is repeated after 7 to 10 days for the confirmation.

Radiography and ultrasonography

  • X-rays and ultrasound are used to identify liver abscesses or other organ involvement in the Amoebiasis infection.

Computer tomography ( CT)

  • There is detailed imaging of scans provided in the test which helps to detect intestinal perforation, liver abscess and extra intestinal infection involved.

  • This also includes the scan of the brain and lungs.

Magnetic Resonance Imaging ( MRI)

  • This test is useful for detecting cerebral Amoebiasis and also the severity of damage caused due to liver abscess.

Liver function test

  • This is conducted when the liver abscess is confirmed. Abnormal activities of the liver confirm the presence of the parasite.

Colonoscopy and Biopsy

  • There is direct visualisation of perforation in the colon and tissue.

  • This is detected through biopsy which is performed to identify the ulcers caused by Amoebiasis.

Chest X-Ray

  • Disgusting process is used in pulmonary complications which is suspected during other tests.

  • This is a rare case of Amoebiasis and is spread throughout the lungs.


Prevention of Amoebiasis

There is no certain way through which you can completely avoid Amoebiasis. But there are certain measures which you can take to prevent Amoebiasis. Some of these are mentioned below:

  • Access to safe and clean drinking water.

  • Hands must be washed regularly with soap and water.

  • Avoid consuming food from unhygienic places.

  • Avoid eating foods which are unwashed and produced raw.

  • Use proper sanitation facilities.

  • Dispose of the sewage properly to prevent contamination.

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Medications for Amoebiasis

Amoebiasis is normally treated with a combination of different medicines at a single time. It is generally advised to visit a doctor to eradicate the parasite from your intestine and also other infected tissues and organs. Some of the commonly used medications are mentioned below:

  • Metronidazole or Tinidazole: Generally used to kill the E.histolytica present in the intestine and other tissues.

  • Paromomycin: One of the luminal agents which is used to eradicate parasites from the intestine.

  • Diloxanide Furoate: Another luminal agent which is used for eliminating cyst carriers.

  • Dehydroemetine: Used in severe cases of extraintestinal Amoebiasis and especially in the case of liver Abscess.

  • Chloroquine: Used with the combination of other drugs to treat Liver Abscess


Tips, Tricks, and Strategies to Prepare for Amoebiasis

It becomes really difficult to remember everything. The solution to this problem is to remember key points using some of the tricks. Some of them are mentioned below:

AMOEBIASIS: Important Points

  • A: Amoeba - caused by a protozoa Entamoeba histolytica.

  • M: Migration: A parasite which migrates to the large intestine and causes damage to the colon.

  • O: Outbreaks: Common diseases in the areas with poor sanitation.

  • E: Exposure: Transmitted through contaminated food and water.

  • B: Bloody diarrhoea: One of the major symptoms which includes diarrhoea with blood.

  • I: Infection: Can lead to extra-intestinal infection like liver Abscess.

  • A: Antigen: Diagnosed using stool test for antigen presence.

  • S: Symptoms: Symptoms can be from mild to severe.

CYSTS: life cycle of E.histolytica

  • C: Cysts: Come from contaminated food and water

  • Y: You: Humans are one of the Primary careers of the cysts.

  • S: Survive: Cysts can survive in the human body for months.

  • T: Trophozoites: Active form of protozoa which causes disease.

Types of Questions Asked on Amoebiasis

During the preparation of the chapter, there are different types of questions asked about Amoebiasis in different kinds of exams. The table given below contains the different patterns of questions asked in different exams.

Exam type

Types of questions asked

CBSE

  • Definition of Amoebiasis and its causes.

  • Symptoms.

  • Methods of Transmission.

  • Risk factors involved in Amoebiasis.

NEET

  • Diagnostic methods used for Amoebiasis.

  • Treatment options for Amoebiasis.

  • Life cycle of Entamoeba histolytica.

  • Stages of the life cycle of Entamoeba histolytica.

Paramedical

  • Management strategies for Amoebiasis

  • Prevention for Amoebiasis.

  • Complications related to Amoebiasis.

  • Liver Abscess.


Weightage of Amoebiasis in Different Entrance Exams

In the table below the weightage of Amoebiasis is discussed according to different year question papers of different entrance exams.


Exam

Weightage

CBSE

4%

NEET

6%

Paramedical

3%

Pharmacy

5%


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Frequently Asked Questions (FAQs)

1. What is another name for Amoebiasis?

Amoebic dysentery is the other name for amoebiasis.

2. What is the prevention for Amoebiasis?

The water should be cleaned not by chlorine treatment but by boiling. The food should be cooked with proper safety. Safe disposal of excreta should be done.

3. What are the three major symptoms of Amoebiasis?

The three major symptoms of Amoebiasis are diarrhoea ( bloody), abdominal pain and fatigue. 

4. What is Luminal amoebiasis?

Luminal amoebiasis is defined as a disease in which no clinical symptoms and signs of a disease are apparent.

5. What is the main cause of the spread of amoebiasis?

Contaminated water is main cause of amoebic dysentery.

6. What is the treatment for Amoebiasis?

The most common treatment for Amoebiasis is medications which involve medicines like Metronidazole or Tinidazole, this is followed by luminal agents like Paromomycin that help in eliminating the cyst.  

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