Cardiac muscles are striated muscle fibres existing in the heart only. They are special because they are rhythmically and involuntarily contracting in nature. This is because the primal function is meant for pumping blood throughout the body. Cardiac muscle cells, also known as cardiomyocytes, interdigitate through special structures called intercalated discs, which enable synchronised contractions of the cardiomyocyte to maintain a brisk heartbeat.
Latest: NEET 2024 Paper Analysis and Answer Key
Don't Miss: Most scoring concepts for NEET | NEET papers with solutions
New: NEET Syllabus 2025 for Physics, Chemistry, Biology
NEET Important PYQ & Solutions: Physics | Chemistry | Biology | NEET PYQ's (2015-24)
Understanding cardiac muscles is important in an attempt to understand how the heart operates and therefore supports and maintains circulation in the body. Research about the physiology of cardiac muscles enables the diagnosis and treatment of many conditions relating to the heart, including arrhythmias, heart attacks, and heart failures. Levels of information regarding cardiac muscle functioning help in the development of treatments and interventions geared at enhancing heart health and the general functionality of the cardiovascular.
Cardiac muscles are explained below-
Cardiac muscles, also the myocardium, are muscle tissues that are unique to the heart. They are characterised by being striated and not under control, with the feature of rhythmical contraction. The cardiac muscles are active without stopping and control by the mind because the force of contraction is provided by intrinsic electrical excitation. They demonstrate intercalated discs with facilities to generate synchronised contractions.
Compared to the skeletal muscles, cardiac muscles are striated but are involuntary, unlike the voluntary control of skeletal muscles. They also differ from smooth muscles in being striated and, in contrast to the non-striated smooth muscles controlling involuntary movement of the organs, exist to work continuously and rhythmically for the pumping of blood.
Cardiac muscles assume properties for continuous, regular contractions which are crucial for the pumping of blood, whereas the skeletal muscles have the responsibility of supporting movement and the smooth muscles managing internal processes.
The histology of Cardiac muscles are explained below-
Cardiac muscle cells (cardiomyocytes)
The cardiomyocytes are the basic unit of functional cardiac muscle, they are cylindrical, striated muscle cells, generally with one nucleus. They are connected by intercalated discs which allow transmission of electrical signals so that the heart muscle can contract in unison.
Striations and intercalated discs
The striations in cardiac muscle are due to the arrangement of filaments made of actin and myosin. Intercalated discs are specialised attachments between the ends of cardiomyocytes. They contain gap junctions, through which the action potential conduction is very fast, and desmosomes, which impart mechanical strength.
Pacemaker cells
Cardiac tissue consists of pacemaker cells and contractile cells. Pacemaker cells occur mainly in the sinoatrial node, the points that generate electric impulses for the sustention of a heartbeat, while the contractile cells are responsible for the mechanical contraction of the heart.
Staining techniques and histological slides
Specific ways of staining are needed for histological studies of cardiac muscle to bring out the different components. Stains like hematoxylin and eosin can identify the striations, nuclei, and intercalated discs. Special stains and electron microscopy will give information about cellular structures and their junctions in detail.
The structure of Cardiac muscles is explained below-
Sarcolemma
The sarcolemma is the membrane of the cell coat, and the sarcoplasm is the cytoplasm, including myofibrils responsible for the cell's contraction. The sarcolemma corresponds to the plasma membrane of cardiomyocytes. It encloses the cell, thus providing the cell with its structure. More importantly, it is responsible for passing action potentials and maintaining the necessary ionic balance for muscle contraction.
Sarcoplasm
Sarcoplasm is the cytoplasm of the cardiomyocyte containing a large number of myofibrils, mitochondria, and other organelles. The nucleus contains the constituents necessary for the processes of muscle contraction and the production of energy, including enzymes and stored glycogen.
Nucleus
Each cardiomyocyte contains one nucleus, which is centrally located. The nucleus controls cellular activities and gene expression necessary for the maintenance of cardiac muscle health and function.
Mitochondria
The number of mitochondria in cardiomyocytes is very great, indicative of the high energy requirements of these cells. Mitochondria are the site of ATP production via aerobic respiration and thus are crucial for maintaining cardiac muscle contraction.
Intercalated discs
These are specialised junctions between the cardiomyocytes that facilitate the mechanical and electrical coupling of adjacent cells. This ensures contractions are synchronised and therefore efficient.
Gap junctions
Gap junctions in the intercalated discs create a pathway for the rapid movement of electrical impulses from one cell to another which makes it possible to co-ordinate contraction that enables the heart to be an efficient pump.
Desmosomes
Desmosomes were discussed as adhesive structures of the cardiomyocytes. They aid in holding tissues together to withstand the forces during contraction.
The myofibrils within the cardiomyocyte are further arranged into a sarcomere, and this arrangement is essentially the generic term for the basic contractile unit. This overlapping arrangement between the thick and thin filaments is responsible for the striated appearance and is the very essence of muscle contractility.
The function of Cardiac muscles are explained below-
Pumping blood
The cardiac muscle contracts and propels blood from the heart's chambers into the arteries. In effect, the process is very crucial in the maintenance of the pressure of blood, hence facilitating circulation effectively.
Maintaining blood pressure
The pressure generated by the force of the cardiac muscle with its multiple contractions maintains the blood pressure within the arterial system, hence enabling the distribution of it to all tissue parts.
The cardiac cells contract starting from impulse conduction by pacemaker cells and, finally, the interaction of actin and myosin filaments by sliding in the sarcomeres.
Excitation-contraction coupling
Excitation-contraction coupling is the process by which the action potential, or electrical excitation, of the heart muscle, leads to its mechanical contraction.
Role of calcium ions
Calcium ions are must-haves for cardiac muscle contraction. They combine with troponin molecules, activators that interact with the actin and myosin filaments. Add to this effect is the sliding over each other of the filaments, hence muscle contraction.
Action potential propagation
Action potentials developed in the sinoatrial node get propagated through the conduction system of the heart—the atrioventricular node, the bundle of His, and the Purkinje fibres. The spread is well-coordinated, and this brings forth a well-synchronized contraction of the heart chambers.
Contractions in cardiac muscle are both involuntary and rhythmic; this is in contrast to the voluntary contractions of skeletal muscles. This property of the cardiac muscles also differs from those of smooth muscle, where contraction and relaxation are sustained with a slower rhythm. The contraction of the cardiac muscles, occurring via the electrical conduction system of the heart, is coordinated for effective pumping.
This cardiac muscle tissue is striated and consists of branched cells joined by intercalated discs. These discs have gap junctions and desmosomes that allow for the transmission of contraction forces and synchronised contractions.
The cells of the cardiac muscle are referred to as cardiomyocytes. The cells are cylindrical and have a single central nucleus. The myofibrils of the cells are segmented into sarcomeres. All cardiomyocytes have a sarcoplasmic reticulum store of calcium and an abundant amount of mitochondria to make ATP, which fuels the constant, rhythmic contractions of the heart.
Cardiac muscles are responsible for pumping blood through the circulatory system, maintaining blood pressure, and providing an effective delivery of oxygen and nutrients to other tissues of the body.
Intercalated discs are involved in the connection of the cardiomyocytes; the gap junctions of these cells provide electrical communication, and the desmosomes provide mechanical strength that allows coordinating contractions of cardiac myocytes.
The electrical impulses cause the contraction of the cardiac muscle and thus increase cytosolic Ca2+ by the release of Ca2+ from the SR. Troponin becomes bound with Ca2+ leading to increased levels, hence permitting the actin-myosin interaction to contract the muscle.
04 Oct'24 10:18 AM
01 Oct'24 01:26 PM
26 Sep'24 06:20 PM
19 Sep'24 10:56 AM
18 Sep'24 07:00 PM
18 Sep'24 03:42 PM
18 Sep'24 03:37 PM
18 Sep'24 03:02 PM
30 Aug'24 10:47 AM
30 Aug'24 10:29 AM