Sympathetic Nervous System: Definition, Function, Disorders

Sympathetic Nervous System: Definition, Function, Disorders

Edited By Irshad Anwar | Updated on Jul 02, 2025 06:51 PM IST

The sympathetic nervous system is part of the autonomic nervous system and is involved in the body's involuntary "fight or flight" response. The structure of the sympathetic nervous system consists of neurons of the spinal cord connected to organs through ganglia. Its function allows for rapid adjustments, such as increased heart rate and blood flow when one experiences stress. Disorders may interrupt these responses and disturb the cardiovascular and metabolic balance. This is one of the important topics from the Neural Control and Coordination chapter of Biology.

This Story also Contains
  1. Sympathetic Nervous System (SNS)
  2. Sympathetic Nervous System Functions
  3. Anatomy of the Sympathetic Nervous System
  4. Physiology of the Sympathetic Nervous System
  5. Sympathetic Nervous System and Homeostasis
  6. Common Disorders and Diseases
Sympathetic Nervous System: Definition, Function, Disorders
Sympathetic Nervous System: Definition, Function, Disorders

Sympathetic Nervous System (SNS)

The sympathetic nervous system consists of one of the two main divisions in the autonomic nervous system the other being the parasympathetic nervous system. It prepares the body for responding to stress or emergencies, which one commonly calls the "fight-or-flight" response. This involuntary action is essential in maintaining homeostasis in the body.

It is important because the SNS can rapidly marshal all the resources of the body during stressful situations to ensure survival. Through its regulation of heart rate, blood pressure, energy mobilisation, and other activities, the SNS allows the body to cope with external challenges while maintaining internal balance.

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Sympathetic Nervous System Functions

Read about the functions of Sympathetic Nervous system functions:

Fight-or-Flight Response:

  • Increases blood pressure

  • Dilates airways

  • Glucose released from energy stores

Effects on Other Organs and Systems:

  • Cardiovascular System: Increases heart rate and blood pressure

  • Respiratory System: Bronchodilators

  • Digestive System: Slows digestion

  • Metabolic Processes: Glucose metabolism

Anatomy of the Sympathetic Nervous System

The SNS anatomy consists of neurons and ganglia that run from the spinal cord to various organs and systems of the body.

Neurons And Neurotransmitters Involved:

  • The SNS is a system composed of preganglionic neurons originating in the spinal cord and postganglionic neurons extending to target organs.

  • Principal neurotransmitters include norepinephrine and epinephrine.

Preganglionic And Postganglionic Neurons:

  • The preganglionic neurons reside within the thoracic and lumbar regions of the spinal cord.

  • The postganglionic neurons reside within the ganglia near or in target organs.

Sympathetic Chain And Collateral Ganglia:

  • The sympathetic chain refers to the row of ganglia that runs down along the vertebral column parallel to the spinal cord.

  • The visceral efferent collateral ganglia are more anterior and associated with major abdominal arteries.

Pathways Of Sympathetic Fibers:

  • There are specific pathways of sympathetic fibres from the spinal cord to their destination organs in connecting either through the ganglia of the sympathetic chain or bypassing it for the collateral ganglia.

Physiology of the Sympathetic Nervous System

The SNS physiology represents the intricate mechanisms of such quick and effective responses.

Mechanisms of Action

  • Activation starts with a stimulus, which causes the hypothalamus to send signals to the spinal cord for the activation of preganglionic neurons.

  • Neurotransmitters: Norepinephrine and Epinephrine these neurotransmitters play a very vital role in transmitting the signal across synapses and in binding with adrenergic receptors on target cells.

  • Receptor Types: Adrenergic Receptors (Alpha and Beta Receptors): Alpha receptors generally cause constriction of blood vessels, while beta receptors increase heart rate and relax airway muscles.

Effects on Different Organs and Systems

  • Cardiovascular System: Increases heart rate and raises blood pressure.

  • Respiratory System: Bronchodilation, thus it eases breathing.

  • Digestive System: Inhibits digestive processes.

  • Urinary System: Affects bladder control.

  • Metabolic Effects: Increases glucose metabolism, and mobilizes energy.

Sympathetic Nervous System and Homeostasis

It is essential in homeostasis because it controls various activities in the body.

Role in Homeostatic Regulation

  • Body Temperature: Maintains body temperature through the control of blood flow to the skin surface and activity of sweat glands.

  • Stress Response and Adaptation: Help the body adjust to stress by liberating cortisol and other stress hormones.

Interactions with the Parasympathetic Nervous System

  • SNS is responsible for the "fight or flight" response, the parasympathetic nervous system is responsible for the "rest and digest" response.

  • The autonomic nervous system has two divisions, sympathetic and parasympathetic, that balance each other's effects to maintain homeostasis.

Common Disorders and Diseases

  • Hypertension: High blood pressure, continued over time, can be influenced by overactivity of the SNS.

  • Heart Failure: The SNS may result in heart failure because of the excess load on it through stress signals.

  • Anxiety Disorders: Overactive activity of SNS is associated with anxiety and panic disorders.

  • Pheochromocytoma: A rare tumour of the adrenal gland that might lead to excess production of adrenaline.

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Frequently Asked Questions (FAQs)

1. What is the primary role of the sympathetic nervous system?

It is an autonomic response for preparing the body for prompt action in stressful situations or emergencies through the fight-or-flight response.

2. What is the action of the sympathetic nervous system on the heart?

The SNS increases the heart rate and force of contraction, increasing blood supply to the vital organs and muscles during stressful conditions.

3. What are the symptoms of an overactive sympathetic nervous system?

Accelerated heartbeat, blood pressure, sweating, anxiety, and high blood sugar are symptoms.

4. How to calm the sympathetic nervous system?

Deep breathing, meditation, yoga, and regular exercise reduce the activity of SNS, thus decreasing the stress in the minds of individuals.

5. Compare and contrast the sympathetic and parasympathetic nervous systems.

The Sypathetic nervous system (SNS) is a preparation of the body to take action, whereas parasympathetic nervous systems play a role in rest and digestion.

6. What is the anatomical structure of the sympathetic nervous system?
The sympathetic nervous system consists of a chain of ganglia (clusters of nerve cell bodies) running parallel to the spinal cord. Preganglionic neurons originate in the thoracic and lumbar regions of the spinal cord and synapse with postganglionic neurons in these ganglia. The postganglionic neurons then extend to various organs and tissues throughout the body.
7. What is the difference between preganglionic and postganglionic neurons in the sympathetic nervous system?
Preganglionic neurons originate in the spinal cord and have short axons that synapse with postganglionic neurons in sympathetic ganglia. Postganglionic neurons have longer axons that extend from the ganglia to target organs. Preganglionic neurons use acetylcholine as a neurotransmitter, while most postganglionic neurons use norepinephrine.
8. What is the relationship between the sympathetic nervous system and the hypothalamus?
The hypothalamus is a key control center for the sympathetic nervous system. It receives and integrates information from various sources and can activate the sympathetic system in response to physical or emotional stress, helping to coordinate the body's "fight or flight" response.
9. How does the sympathetic nervous system affect the reproductive organs?
The sympathetic nervous system generally inhibits reproductive functions. In males, it can cause contraction of the vas deferens and seminal vesicles, contributing to ejaculation. In females, it can inhibit uterine contractions and reduce blood flow to reproductive organs.
10. How does the sympathetic nervous system affect the gastrointestinal tract?
The sympathetic nervous system generally inhibits gastrointestinal function. It decreases peristalsis, reduces blood flow to the digestive organs, and inhibits the secretion of digestive enzymes. This allows the body to redirect energy and resources to more critical functions during stress or emergencies.
11. What is sympathetic nervous system fatigue?
Sympathetic nervous system fatigue, also known as adrenal fatigue, is a controversial concept suggesting that prolonged stress can exhaust the body's stress response system. It's characterized by symptoms like fatigue, weakness, and difficulty coping with stress. However, it's not widely recognized as a medical diagnosis.
12. What is sympathetic nervous system overactivity?
Sympathetic nervous system overactivity refers to a state of excessive or prolonged activation of the sympathetic system. This can lead to chronic stress, hypertension, cardiovascular problems, and other health issues. It may be caused by various factors, including chronic stress, certain medical conditions, or lifestyle factors.
13. What is sympathetic nervous system dominance, and when does it occur?
Sympathetic nervous system dominance occurs when the sympathetic system is more active than the parasympathetic system. This typically happens during stress, exercise, or emergencies, preparing the body for action. Prolonged sympathetic dominance can lead to chronic stress and associated health problems.
14. What is the role of the sympathetic nervous system in pain perception?
The sympathetic nervous system can modulate pain perception. In acute stress situations, it can reduce pain sensitivity through the release of endogenous opioids and other mechanisms. However, in some chronic pain conditions, sympathetic activity may contribute to pain amplification.
15. How does the sympathetic nervous system affect the immune system?
The sympathetic nervous system can modulate immune function. Short-term activation can enhance immune responses, while chronic activation (as in prolonged stress) can suppress immune function. This occurs through direct innervation of immune organs and the effects of stress hormones on immune cells.
16. What is the sympathetic nervous system?
The sympathetic nervous system is a part of the autonomic nervous system that prepares the body for "fight or flight" responses. It increases heart rate, breathing rate, and blood flow to muscles while decreasing digestion and other non-essential functions during stressful or emergency situations.
17. What is sympathetic nervous system plasticity?
Sympathetic nervous system plasticity refers to the ability of the sympathetic system to adapt and change in response to various stimuli or conditions. This can involve changes in neurotransmitter release, receptor expression, or nerve growth and can be important in both normal physiological adaptations and disease processes.
18. What is sympathetic nervous system-dependent pain?
Sympathetic nervous system-dependent pain refers to pain that is maintained or exacerbated by sympathetic nervous system activity. This can occur in certain chronic pain conditions where there's an abnormal interaction between sympathetic nerves and pain-sensing nerves.
19. What is sympathetic nervous system withdrawal?
Sympathetic nervous system withdrawal refers to a sudden decrease in sympathetic activity. This can occur after periods of high stress or during certain medical conditions. It can lead to symptoms such as fatigue, dizziness, or even fainting due to a rapid drop in blood pressure.
20. What is sympathetic nervous system remodeling?
Sympathetic nervous system remodeling refers to structural and functional changes in sympathetic nerves and their targets in response to chronic conditions or injuries. This can involve changes in nerve density, neurotransmitter release, or receptor expression, and may contribute to the progression of various diseases.
21. What are the main neurotransmitters involved in the sympathetic nervous system?
The primary neurotransmitters in the sympathetic nervous system are norepinephrine (noradrenaline) and epinephrine (adrenaline). These chemicals are released at nerve endings to activate target organs and tissues, producing the "fight or flight" response.
22. How does the sympathetic nervous system affect the heart?
The sympathetic nervous system increases heart rate and contractility. It does this by releasing norepinephrine, which binds to beta-1 receptors on heart muscle cells. This increases the rate and force of heart contractions, preparing the body for action.
23. What is the "fight or flight" response, and how is it related to the sympathetic nervous system?
The "fight or flight" response is the body's automatic physiological reaction to perceived threats or stress. It is primarily mediated by the sympathetic nervous system, which rapidly activates various body systems to prepare for immediate action, whether to confront the threat (fight) or escape from it (flight).
24. How does the sympathetic nervous system affect the pupils of the eyes?
The sympathetic nervous system causes pupil dilation (mydriasis). This allows more light to enter the eye, improving vision in low-light conditions or when increased visual acuity is needed during stressful situations.
25. How does the sympathetic nervous system affect blood vessels?
The sympathetic nervous system generally causes vasoconstriction (narrowing) of blood vessels in most parts of the body. However, it causes vasodilation (widening) in skeletal muscles and the coronary arteries. This redirects blood flow to the muscles and heart, preparing the body for physical exertion.
26. How does the sympathetic nervous system affect the skin?
The sympathetic nervous system causes piloerection (goosebumps) by contracting arrector pili muscles attached to hair follicles. It also increases sweat production and can cause pallor (paleness) due to vasoconstriction of blood vessels in the skin.
27. How does the sympathetic nervous system affect the bladder?
The sympathetic nervous system relaxes the detrusor muscle of the bladder wall and contracts the internal urethral sphincter. This inhibits urination, allowing the body to retain urine during stressful situations when emptying the bladder might be inconvenient or dangerous.
28. How does the sympathetic nervous system affect the liver?
The sympathetic nervous system stimulates the liver to release glucose into the bloodstream through glycogenolysis (breakdown of glycogen) and gluconeogenesis (production of new glucose). This provides readily available energy for the body during stressful situations.
29. What is the role of the sympathetic nervous system in thermoregulation?
The sympathetic nervous system plays a crucial role in thermoregulation by controlling sweat glands, blood vessel dilation/constriction, and piloerection. These mechanisms help the body maintain its core temperature in response to environmental changes or internal heat production.
30. What is sympathetic tone, and why is it important?
Sympathetic tone refers to the baseline level of activity in the sympathetic nervous system. It's important because it maintains a constant, low-level stimulation of various organs and tissues, allowing for rapid adjustments in response to changing physiological needs or environmental conditions.
31. What role does the sympathetic nervous system play in digestion?
The sympathetic nervous system generally inhibits digestion. It decreases blood flow to the digestive organs, reduces the production of digestive enzymes, and slows down peristalsis (the movement of food through the digestive tract). This allows the body to redirect energy and resources to more critical functions during stress or emergencies.
32. How does the sympathetic nervous system affect sweat glands?
The sympathetic nervous system stimulates sweat glands to increase sweat production. This helps regulate body temperature during stress or physical exertion by promoting heat loss through evaporation.
33. How does the sympathetic nervous system differ from the parasympathetic nervous system?
The sympathetic nervous system prepares the body for action and stress, while the parasympathetic nervous system promotes rest and digestion. The sympathetic system increases heart rate and blood pressure, while the parasympathetic system decreases them. They work in opposition to maintain balance in the body.
34. What is the role of the adrenal glands in the sympathetic nervous system?
The adrenal glands, particularly the adrenal medulla, play a crucial role in the sympathetic nervous system. When stimulated by sympathetic nerves, the adrenal medulla releases epinephrine and norepinephrine directly into the bloodstream, amplifying and prolonging the sympathetic response throughout the body.
35. How does the sympathetic nervous system affect breathing?
The sympathetic nervous system increases the rate and depth of breathing. It does this by stimulating the bronchi to dilate, which allows more air to enter the lungs. This ensures that the body receives more oxygen to support increased physical activity during stressful situations.
36. How does the sympathetic nervous system affect the pancreas?
The sympathetic nervous system inhibits insulin secretion from the pancreas while stimulating glucagon release. This leads to an increase in blood glucose levels, providing readily available energy for the body during stressful situations.
37. How does the sympathetic nervous system affect the kidneys?
The sympathetic nervous system stimulates the kidneys to increase renin production, which activates the renin-angiotensin-aldosterone system. This leads to increased sodium and water retention, and vasoconstriction, ultimately raising blood pressure to support the "fight or flight" response.
38. How does the sympathetic nervous system affect sleep?
The sympathetic nervous system is generally less active during sleep, particularly during deep sleep stages. However, increased sympathetic activity can interfere with sleep onset and quality. This is why stress or anxiety can often lead to sleep disturbances.
39. What is the relationship between the sympathetic nervous system and chronic pain?
The sympathetic nervous system can play a role in chronic pain conditions. In some cases, such as complex regional pain syndrome, there may be abnormal interactions between sympathetic nerves and pain-sensing nerves. This can lead to pain amplification and maintenance of chronic pain states.
40. How does the sympathetic nervous system affect blood sugar levels?
The sympathetic nervous system tends to increase blood sugar levels. It does this by stimulating the liver to release glucose through glycogenolysis and gluconeogenesis, inhibiting insulin secretion from the pancreas, and promoting glucagon release. This provides readily available energy during stress or emergencies.
41. What is the role of the sympathetic nervous system in exercise?
During exercise, the sympathetic nervous system is activated to support increased physical activity. It increases heart rate and contractility, dilates blood vessels in skeletal muscles, increases breathing rate, stimulates glucose release, and enhances sweating for thermoregulation.
42. How does aging affect the sympathetic nervous system?
Aging can lead to changes in sympathetic nervous system function. These may include increased baseline sympathetic activity, reduced responsiveness to stressors, and alterations in neurotransmitter release and receptor sensitivity. These changes can contribute to age-related cardiovascular and metabolic issues.
43. How does the sympathetic nervous system interact with the endocrine system?
The sympathetic nervous system interacts closely with the endocrine system, particularly through the hypothalamic-pituitary-adrenal (HPA) axis. Sympathetic activation can trigger the release of stress hormones like cortisol, while these hormones can, in turn, influence sympathetic activity, creating a complex feedback loop.
44. How does the sympathetic nervous system affect wound healing?
The sympathetic nervous system can influence wound healing through its effects on blood flow, inflammation, and immune function. While acute sympathetic activation can initially promote healing by increasing blood flow to injured areas, chronic sympathetic overactivity may impair wound healing by reducing blood flow and altering immune responses.
45. What is the role of the sympathetic nervous system in blood pressure regulation?
The sympathetic nervous system plays a crucial role in blood pressure regulation. It can increase blood pressure by causing vasoconstriction, increasing heart rate and contractility, and stimulating the kidneys to retain sodium and water. Chronic sympathetic overactivity is associated with hypertension.
46. How does the sympathetic nervous system affect metabolism?
The sympathetic nervous system generally increases metabolic rate. It stimulates the breakdown of glycogen and fat, increases glucose production, and enhances cellular energy expenditure. This metabolic boost helps provide energy for the "fight or flight" response.
47. How does the sympathetic nervous system affect the lungs?
The sympathetic nervous system causes bronchodilation (widening of the airways) in the lungs. This allows for increased airflow, supporting the increased oxygen demands during stress or physical activity. It also increases the rate and depth of breathing.
48. What is the relationship between the sympathetic nervous system and stress?
The sympathetic nervous system is a key mediator of the body's stress response. When the brain perceives stress, it activates the sympathetic system, triggering the "fight or flight" response. Chronic stress can lead to persistent sympathetic activation, which may contribute to various health problems.
49. How does the sympathetic nervous system affect saliva production?
The sympathetic nervous system generally reduces saliva production and makes saliva more viscous (thicker). This is part of the body's response to redirect resources away from digestive functions during stress or emergencies.
50. What is sympathetic nervous system-mediated inflammation?
Sympathetic nervous system-mediated inflammation refers to the influence of sympathetic activity on inflammatory processes. While acute sympathetic activation can have anti-inflammatory effects, chronic sympathetic activation may promote inflammation through the release of neurotransmitters that interact with immune cells.
51. How does the sympathetic nervous system affect the spleen?
The sympathetic nervous system causes contraction of the spleen, which releases stored red blood cells into circulation. This increases oxygen-carrying capacity in the blood, supporting the increased oxygen demands during stress or physical activity.
52. What is the role of the sympathetic nervous system in circadian rhythms?
The sympathetic nervous system plays a role in maintaining circadian rhythms, particularly in regulating the sleep-wake cycle. Sympathetic activity tends to be higher during waking hours and lower during sleep, helping to coordinate various physiological processes with the body's internal clock.
53. How does the sympathetic nervous system affect muscle tension?
The sympathetic nervous system can increase muscle tension by enhancing the excitability of motor neurons. This prepares the muscles for rapid action in response to stress or threats. Chronic sympathetic activation can contribute to muscle tension and associated pain in conditions like tension headaches or fibromyalgia.
54. What is sympathetic nervous system pruning?
Sympathetic nervous system pruning refers to the natural process of refining sympathetic innervation during development. Excess sympathetic nerve connections are eliminated, leaving only the most appropriate and efficient connections. This process is crucial for the proper functioning of the mature sympathetic nervous system.
55. How does the sympathetic nervous system affect cognitive function?
The sympathetic nervous system can influence cognitive function through its effects on arousal and attention. Moderate sympathetic activation can enhance alertness and cognitive performance. However, excessive activation (as in severe stress) can impair certain cognitive functions, particularly those involving complex decision-making or memory recall.

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