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    Biotechnology: Antibodies & their role in Therapeutics

    BY
    Udemy

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    Mode

    Online

    Fees

    ₹ 3099

    Quick Facts

    particular details
    Medium of instructions English
    Mode of learning Self study
    Mode of Delivery Video and Text Based

    Course and certificate fees

    Fees information
    ₹ 3,099
    certificate availability

    Yes

    certificate providing authority

    Udemy

    The syllabus

    Introduction

    • Introduction

    Structure of Antibodies/Immunoglobulin

    • Basic Structure of immunoglobulin or antibodies
    • Functional components of Antibodies
    • Summary- Basic structure of antibodies
    • Antibody sequencing to know different types of light and heavy chains of Abs
    • Types of light chains
    • Types of heavy chains
    • Quiz on structure of antibodies

    Detailed Structure of Antibodies/Immunoglobulin

    • Immunoglobulin Domains
    • Complementarity determining regions (CDRs)
    • Framework region
    • Binding of antigen to CDRs
    • Role of Hinge Region
    • Summary- Detailed structure of antibodies
    • Quiz

    Antibody classes and their biological activities

    • Immunoglobulin G or IgG
    • Immunoglobulin A or IgA
    • Immunoglobulin M or IgM
    • Immunoglobulin E or IgE
    • Immunoglobulin D or IgD
    • Summary- Antibody classes and their biological activities
    • Quiz on functions of antibodies

    Complement System

    • Introduction to complement system
    • Nomenclature of complement proteins
    • Classical pathway of complement activation
    • Alternative pathway of complement activation
    • Lectin Pathway of complement activation
    • Membrane Attack Complex (MAC)
    • Summary- Complement system
    • Quiz on complement system
    • Regulation of the complement system
    • Other functions of complement proteins
    • Quiz on regulation of the complement system

    Organization of immunoglobulin genes

    • Germline & somatic hypermutation Theory
    • Tonegawa’s Theory- Immunoglobulin genes rearrange
    • Organization of Ig genes
    • Organization of gene segments encoding light chains
    • Organization of gene segments encoding heavy chains
    • Quiz on organization of immunoglobulin genes

    V(D)J Recombination

    • VJ recombination in kappa light chain DNA
    • VJ recombination in ƛ light chain DNA
    • VDJ recombination in heavy chain DNA
    • Quiz on V(D)J recombination
    • Mechanism of variable region DNA rearrangements
    • Quiz

    Generation of antibody diversity

    • Combinatorial VJ and VDJ joining
    • Junctional Flexibility
    • P-addition
    • N-addition
    • Somatic Hypermutation
    • Quiz on generation of antibody diversity

    Expression of immunoglobulin genes

    • Class switching
    • Mechanism of class switching
    • Factors that govern class switching
    • Quiz on class switching

    Membrane bound and secreted Antibodies/Immunoglobulin

    • Membrane bound immunoglobulins and BCRs
    • Expression of membrane bound or secreted Immunoglobulin
    • Simultaneous expression of IgM and IgD on mature B cells
    • Quiz on mIg and sIg

    Regulation of Immunoglobulin gene transcription

    • Regulatory sequences in DNA
    • Allelic exclusion
    • Mechanism of allelic exclusion
    • Quiz on Ig gene regulation

    Antigenic determinants/Epitopes on Immunoglobulin

    • Isotypic determinants
    • Role of anti-isotype antibodies in detection of viral diseases
    • Allotypic determinants
    • Idiotypic determinants
    • Types of anti-ID antibodies
    • Specific uses of anti-ID antibodies
    • Quiz on antigenic determinants on immunoglobulins

    Polyclonal and Monoclonal Antibodies

    • Polyclonal Antibodies
    • Monoclonal Antibodies
    • Hybridoma Technology (Production of Monoclonal Antibodies)
    • Selection of Hybridoma cells producing Monoclonal Antibodies
    • Quiz on Polyclonal and Monoclonal Antibodies

    Antibody Engineering

    • Advantages of therapeutic monoclonal antibodies over conventional drugs
    • Chimeric Monoclonal Antibodies
    • Humanized Monoclonal Antibodies
    • Fully Human Monoclonal Antibodies
    • Isolation of monoclonal antibodies directly from humans
    • Immunogenicity of engineered monoclonal antibodies
    • Quiz on antibody engineering

    Monoclonal Antibody Therapy

    • Immunotoxins
    • Recombinant Immunotoxins
    • Humanised and Fully Human Immunotoxins
    • Bispecific Antibodies or Heteroconjugates
    • Abzymes
    • Quiz on Monoclonal Antibody Therapy

    Covalescent Plasma Therapy for the treatment of COVID-19 disease

    • Structural proteins of SARS-CoV-2
    • What is Plasma Therapy or Passive Immunization?
    • How is plasma therapy done?
    • Limitations of Plasma Therapy
    • Quiz on Plasma Therapy

    Monoclonal antibody therapy for the treatment of COVID-19 disease

    • Monoclonal antibodies and COVID-19
    • Isolation of monoclonal antibodies from COVID-19 recovered patients
    • How plasma therapy & monoclonal antibody therapy are different from vaccination?
    • Quiz on monoclonal antibody therapy for COVID-19

    What's next?

    • What's next?

    Instructors

    Ms Roohi Bansal

    Ms Roohi Bansal
    instructor
    Freelancer

    Other Masters, Ph.D

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