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Quick Facts
| Medium Of Instructions | Mode Of Learning | Mode Of Delivery |
|---|---|---|
| English | Self Study | Video and Text Based |
Course Overview
The Structural Biology certification syllabus has been purposefully designed for Biological Sciences, Biosciences, and Bioengineering students. Over 12 weeks, it will educate you on structural units forming biological macromolecules. Their hierarchies, pros & cons, and visualizing 3D structure files will also be discussed.
Approved by AICTE, the Structural Biology course by Swayam will also introduce you to molecular dynamics using various case studies. So, you will know how to apply the acquired knowledge effectively.
The Structural Biology certification course links biological events to deduce how biological macromolecules are folded, generated, and become functional. As such, the course will equip you to take on further advanced studies in drug designing and macromolecule-based engineering.
Swayam offers the Structural Biology program at an introductory level. Replete with case studies, books, and references, the course ensures you have a holistic learning experience. And if you want to certify your learnings, you can also take the certification exam and obtain the course certificate.
The Highlights
- Introductory course
- A course by IIT Roorkee
- Online learning
- E-certificate
- Free enrolment
- UG/PG level course
- A course in Biological Science and Bioengineering
- Case studies
- FDP course
- Approved by AICTE
Programme Offerings
- online learning
- Free registration
- UG/PG level course
- course certificate
- introductory course
- Weekly lectures
Courses and Certificate Fees
| Fees Informations | Certificate Availability | Certificate Providing Authority |
|---|---|---|
| INR 1000 | yes | IIT Roorkee |
- You don't need to pay to enroll in the Structural Biology course by Swayam.
- The course certificate costs Rs 1,000.
The Structural Biology fee structure
Course Option | Fee |
Structural Biology (Program content access only) | FREE |
Structural Biology (Certificate + course content access) | Rs. 1,000 |
Eligibility Criteria
While there are no specific prerequisites for registering in the Structural Biology program, having a basic knowledge of Biology will help in comfortable learning.
Moreover, Swayam only offers the Structural Biology certificate to candidates who meet the two qualification conditions. Your average assignment score should be >= 10/25, and your exam score needs to be >= 30/75.
25% of your average assignment score, calculated using 8 of your assignments with the best scores, and 75% of your exam score are added to determine the final score. Your final score must be >= 40/100 to qualify for the course certificate.
What you will learn
Structural Biology online course will help you master the following topics:
- Protein architecture
- Structural Biology techniques
- Nuclear Magnetic Resonance (NMR)
- 3D Structure visualisation
- Molecular dynamics
- Macromolecular Crystallography
- Protein folding
- Enzymes
Who it is for
Students and research scientists studying/working in disciplines like Pharmaceuticals, Bioinformatics, Biotechnology, Chemistry, and related programs can benefit from taking the Structural Biology course by Swayam. Veterinarians and clinicians who want to undertake research can also join this introductory course.
Admission Details
Step 1: Use the web link https://onlinecourses.nptel.ac.in/noc22_bt28/preview to access the Structural Biology online course by Swayam.
Step 2: Now, find the 'Register/Sign-up' button on the webpage and tap it. Swayam's online registration page will open.
Step 3: You can log in via social accounts (Swayam/Facebook/Microsoft/Google) or start a new learning account by providing the details as asked. Once registered, fill the online form.
Step 4: Swayam will notify you by sending a mail to your registered email ID on successful enrolment.
Application Details
The structural Biology program has a dedicated application form that you need to fill out. You can access it by signing up on Swayam. To do so, you must provide a username, password, and email address to complete the form and press 'submit'. You will receive an email on successful registration.
The Syllabus
Introduction
- Flow of the history of biological inventions
- Basic Biological Macromolecules of life, i.e., Protein, Nucleic Acid, Carbohydrates & Lipid/Fat
- A comparison between polymers and "3C"ecrets of covalent bond, nucleic acid, DNA sequencing, PCR innovation
- Gene sequencing to genome sequencing
- Introduction to NGS and its different platforms
- Arrival of Post Genomic Era
- The effect of HGP
- Experimental three-dimensional structure determination techniques
Protein
- Amino acids and their properties
- Protein Chemistry
- Chirality
- Peptide bond
- Levels of protein structures
- Dihedral angles
- Peptide bond and Ramachandran Plot
- Super Secondary Structures
- Motif
- Domains
- Non-covalent interactions
- Folding of Protein
- Thermodynamics and Kinetics of protein folding
- Characterization of Proteins
Introduction to Structural Biology Techniques
- Cellular organization
- Resolution structure determining technique with their ranges of the resolution
- The success of X-ray crystallography from single molecule to a crystal
- X-ray Crystallography
- Crystallization in X-ray Crystallography
- Crystal mounting in X-ray Crystallography
X-ray Crystallography
- Production of X-ray and its properties
- Unit cell
- Symmetry and lattice
- The geometry of the crystal system
- Crystal Symmetry
- Instrumentation in X-ray Crystallography
- Data collection and processing
X-ray Crystallography
- Data Analysis of X-ray Crystallography - Diffraction Patterns
- Indexing
- Bragg's Law
- Laue equation
- Relation between "Laue equation and Bragg's Law"
- Lattice Transformation
- Ewald Sphere
- Laue Condition for Diffraction and Ewald Sphere
- Structure Factors and Diffraction Pattern
- Atomic Scattering Factor
- Anomalous Dispersion
- Analytical expression of the phase
- Fourier Transformation
- Introduction to Phase Problem
- Phase problem - Phase Problem
- Patterson Function
- How to solve phase problem
- Heavy atom replacement methods
- Isomorphous replacement
- Anomalous dispersion
- Phase problem associated with crystal diffraction and common techniques to recover phase resolving different phase improvement methods
- Refinement and Structure deposition to PDB - aspects of structure refinement, motivation, application, The procedure of simulated annealing, PDB repository, atomic model deposition as well as different PDB validation suites
NMR
- Introduction to NMR
- Basic Principles of NMR and Instrumentation
- NMR Sample Preparation and Chemical Shift related concepts
- Factors effecting NMR Spectra (1D & 2D), 2D & 3D NMR Spectroscopy focusing on protein structure
Spectroscopy
- Introduction to Spectroscopy
- UV-Vis and CD spectroscopy
- Fluorescence Spectroscopy and Green Fluorescence Protein (GFP)
- Infrared & Raman Spectroscopy for protein
- Raman Spectroscopy
- Raman Microscopy and Raman Crystallography for studying protein
Microscopy
- Introduction to Microscopy
- Functioning details of Cryo-Electron Microscopy (Cryo-EM)
- Cryo-Electron Microscopy: Data Collection and Analysis
- A concise story of advancement Cryo-EM
- Protein Data Bank
Molecular Visualizations
- History of Molecular Visualizations of Biological Macromolecules
- Description of structure-related files (.pdb, .mmcif, .mtz, etc.)
- Demonstration of COOT
- 3D visualization using Pymol
- Demonstration of Pymol
Molecular Dynamic Simulation
- Why we need MD Simulation
- Molecular Dynamic Simulation Process
- Build a realistic atomistic model of the system
- The algorithm behind simulation process
- Concept of Topology and Parameter files
- Major components in a force field, the concept of solvation
- Solvent models
- Periodic Boundary Condition
- Concept of Central Simulation Box
- Phase Space
- Concept of Ensembles
- Energy Minimization (EM)
- Potential energy surface (PES)
- Determination of EM
- Types of EM methods and their algorithms
- Steps in MD Simulation
- Application of Molecular Dynamic Simulation
Protein Engineering
- What, How & Which of Protein Engineering
- How to make logical Protein Engineering: Process of Rational design
- A success story of Rational Protein designing: Focusing on De Novo Process
- Designing Protein by mimicking nature: Process of Directed Evolution
- Achievement, Challenges and Future direction in the field of Protein Engineering
Structure-Based Drug Discovery
- Introduction to Structure-Based Drug Discovery (SBDD)
- Rational Drug Discovery
- Docking Based Virtual Screening: Progress, Challenges and Future perspective
- What makes a small molecule an ideal drug: Developing in silico ADMETox Model
- Structure-Based Drug Discovery: Case study and Conclusion
Evaluation process
You must appear for the optional certification exam conducted by Swayam to receive the Structural Biology certificate. The exam will take place in person at one of Swayam's designated exam centers, and it will be proctored.
Exams are held in two slots, namely morning session (9 AM – 12 noon) and afternoon session (2 PM – 5 PM). You can register once they announce the exam and open the portal.
Instructors
IIT Roorkee Frequently Asked Questions (FAQ's)
Yes. Having a basic knowledge of Biology may have helped, but since the Structural Biology program is offered at the introductory level, you can still join it.
Other than the weekly lectures, there will be assignments, case studies, and one optional proctored exam towards the course end.
Yes. It is an AICTE-approved FDP for Faculty Development Program.
Yes. The entire curriculum will be instructed in English.
Yes. The Structural Biology certificate will also have your name and photograph along with your final score.