Biomolecules - Types, Structure and Function

Biomolecules are complex lifeless chemical substances that we get from living tissues. Biomolecules are the organic compounds that are essential for the maintenance of metabolic processes. Biomolecules not only build up the living cells but also help in their growth, development, and ability to reproduce. Examples of biomolecules are carbohydrates, proteins, lipids, and nucleic acids.

JEE Main 2025: Chemistry Formula | Study Materials | High Scoring Topics | Preparation Guide

JEE Main 2025: Syllabus | Sample Papers | Mock Tests | PYQs | Study Plan 100 Days

NEET 2025: Syllabus | High Scoring Topics |  PYQs

This Story also Contains

1. Important Topics Of Biomolecules
2. Overview Of Biomolecules
3. Carbohydrates
4. Proteins
5. Amino acids
6. Nucleic acids
7. How To Prepare For Amines?
8. Book for Biomolecules

This article will give you all the information regarding the biomolecules chapter. This will help you to make your strategies in your preparation and it will also guide you in how to prepare for this chapter and the best-prescribed books

Important Topics Of Biomolecules

Classification Of Carbohydrates And Its Structure:

Carbohydrates are composed of carbon, hydrogen, and oxygen; the general formula is Cx(H2O)y. They are categorized based on their degree of polymerization as monosaccharides, disaccharides, oligosaccharides, and polysaccharides. Monosaccharides consist of the simplest units of carbohydrates, which cannot be further hydrolyzed into still smaller carbohydrate molecules. Two monosaccharides are then linked together via a condensation reaction to form a single disaccharide. Oligosaccharides and polysaccharides are chains of monosaccharide units.

Tests For Carbohydrates:

Several chemicals are used in the tests for carbohydrates because of the peculiar characteristics of each compound. Because Each body is specific for a certain type of carbohydrate such as the benedict test is applicable in determining reducing sugars, for example, glucose and fructose, iodine test is designed for identifying starch, whereby an iodine solution changes to a blue-black color on coming into contact with a sample of the starch.

Properties Of Glucose:

Glucose exhibits a couple of Properties, which make it suitable to play the above-mentioned biological roles. First, it is known as a reducing sugar in that it has the ability to reduce other oxidizing agents. Glucose is oxidized with nitric acid, saccharic acid is formed. Saccharic acid is also known as glucaric acid.

Amino Acids:

Amino Acids are the very building blocks of proteins, and proteins are the most fundamental macromolecules in any living organism. These organic compounds perform critical functions not only towards the structure of cells but also in various physiological activities, as diverse as muscle contraction and the activation of the immune system.

Proteins:

Proteins are large, complex molecules consisting of chains of amino acids. Amino acids are organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and on rare occasions, sulfur. They have vital roles in structure, function, and regulation in the body's tissues and organs.

Enzymes:

Enzymes are specialty proteins that function as catalysts in biochemical reactions—that is, they speed up reactions but they are not consumed in the reaction. Each enzyme is specific to one reaction or type of reaction. It often binds to a substrate, the molecule upon which the enzyme acts. This interaction lowers the activation energy required for the reaction to proceed.

Vitamins:

Vitamins are organic materials that the body requires for proper metabolism and which are only required in trace amounts. They take part in many functions of our bodies: starting with support to our immune system and ending with the production of energy.

Overview Of Biomolecules

Types of Biomolecules

There are four types of biomolecules:

• Carbohydrates
• Lipids
• Proteins
• Nucleic acids

Carbohydrates

Carbohydrates are the optically active polyhydroxy aldehydes or polyhydroxy ketones or substances that produce them on hydrolysis. Carbohydrates play a vital role in our daily life. They provide us the the three basic necessary things of life which are food (starch), clothing (cellulose), and shelter (cellulose).

Classification of Carbohydrates

Carbohydrates are also known as the saccharides. And classified into three categories

• Monosaccharide
• Oligosaccharides
• Polysaccharides

Monosaccharides

It cannot hydrolysis to the smaller molecules. Their general formula is (CH₂O)n where n= 3-7.

Oligosaccharides

These on hydrolyzed give 2-10 molecules of monosaccharides like Disaccharides, Trisaccharides, and Tetrasaccharides.

Polysaccharides

Carbohydrates in hydrolysis give a large number of monosaccharide units such as Starch, cellulose, and glycogen.

Reducing and Non-reducing Sugars
Those sugars that reduce Fehling's and Tollens's solutions are called reducing sugars and those that do not reduce these reagents are called non-reducing sugars. All the monosaccharides and disaccharides, except sucrose, are reducing sugars, whereas all the polysaccharides are called non-reducing carbohydrates.

Cyclic Structure of Carbohydrates

The CHO group of glucose either reacts with the C-5 OH group or the C-4 OH group to give hemiacetalic linkage and forms stable six- and five-membered cyclic rings, respectively. If the CHO group reacts with the C-6 OH group, then a less stable seven-membered ring will form, or with C-3 OH, a four-membered ring will be formed, both are unstable.

Haworth representation: The cyclic structure of glucose was established by English chemist W.N. Haworth. The cyclic structure of glucose is depicted below.

Proteins

Proteins are the condensation polymer of the alpha-amino acids. They are present in almost all the living cells of plants and animals. In human beings, proteins are the main components of muscles, hairs, nails, tendons, arteries, and connective tissues. Each living cell is made up of thousands of different proteins.

Structure of Proteins

1) Primary Structure -Proteins may have one or more polypeptide chains. Each polypeptide in a protein has amino acids linked with each other in a specific sequence and it is this sequence of amino acids that is said to be the primary structure of that protein. Any change in this primary structure i.e., the sequence of amino acids creates a different protein.

2) Secondary Structure- Two types of secondary structure are alpha helix and beta plotted sheet structure which are held by hydrogen bonds.

3) Tertiary Structure -Tertiary structure is the interaction between protein molecules in a 3D manner which involves a disulfide bond, Hydrogen bond, and Ionic bond.

4) Quaternary Structure - Quaternary structure is an association of protein molecules in close arrangement.

The diagrammatic representation of all these structures is shown below:

Amino acids

Amino acids contain amino (-NH₂) and carboxyl (-COOH) as functional groups. Depending upon the relative positions of the -NH₂ group w.r.t -COOH group, the amino acids are classified as alpha, beta, gamma, delta, etc. amino acids. However, only alpha amino acid is obtained during the hydrolysis of protein. so that alpha amino acid is the building block of proteins

There are 20 amino acids in almost all proteins and these determine the properties of amino acids

Amino acids have amino(-NH₂) and carboxyl(-COOH) functional groups. Based on the relative position of the two functional groups in the alkyl chain, the amino acids are categorized as α, β,? δ and so on. On the hydrolysis of proteins, only α-amino acids are formed. Amino acids may also contain other functional groups.

• Amino acids which can be synthesized in our body are known as non-essential amino acids while those that can not be synthesized in our body are known as essential amino acids.
• They are usually colorless, water-soluble, high melting and crystalline solids.
• Except glycine, all other naturally occurring amino acids are optically active.
• Most naturally occurring amino acids have L-configuration.

Nucleic acids

Nucleic acid is the polymer present in the living system. Nucleic acids are also called polynucleotides because their repeating unit is a nucleotide. Nucleotides contain three parts i.e. a sugar molecule, a nitrogenous base, and a phosphoric acid.

Structure of Nucleic acids

The structure of nucleic acid contains:

• A pentose sugar: pentose sugar in DNA is called deoxyribose

pentose sugar in RNA is called ribose

• Nitrogenous base: 1) Purines

2) Pyridines

• Nucleoside and Nucleotide: Nucleosides contain pentose sugar and nitrogenous base

Nucleotides contain a sugar, base, and a phosphate group

A double helix consists of two strands that are antiparallel and complementary to each other. Two helixes are held together by hydrogen bonds.

Function of biomolecules

Biomolecules are essential components of life and perform various functions such as:

• Carbohydrates are the source of energy they store energy and help in the recognition of cells
• Proteins help in the transportation of molecules across the cell membranes
• Lipids form the cellular membrane and provide insulation and protection to the organs.
• Nucleic acids store the genetic information and help in protein synthesis.

How To Prepare For Amines?

• This chapter is part of organic chemistry. It is completely theory-based. You are not supposed to memorize any formulas and numerical practice to get a good hold of this chapter. All you just need to remember is reaction mechanisms and important reactions.

• In a nutshell, it can be said that although this chapter is lengthier than other chapters, it is a very simple and straightforward one. So always say a "Big YES" to this chapter.

Book for Biomolecules

For this chapter, first, you need to finish the important topics of biomolecules class 12 thoroughly from the class 12th NCERT book and then simultaneously solve the examples and questions given in the book.