Get updates on Eligibility, Admission, Placements Fees Structure
Quick Facts
| Medium Of Instructions | Mode Of Learning | Mode Of Delivery | Frequency Of Classes |
|---|---|---|---|
| English | Self Study, Virtual Classroom | Video and Text Based | Weekdays, Weekends |
Course Overview
Molecular Modelling certification is a one and a half month course that is a joint contribution of Edu Plus Now, and the Indian Statistical Institute, Pune. The entire course is held for a total of 28 hours by a complete set of academicians and experts from the concerned industries. The classes are conducted by building a virtual environment where students are allowed to interact with their teachers and their peers. This encourages network building exercises among the participants.
Molecular Modelling training will include studies related to the aspects of ligand- and receptor-based drug design. The topics also will be related to homology modelling, energy minimization, macromolecule optimization, active site identification, molecular dynamics simulation, domain analysis, and more. These will actually help the participants in gaining valuable insights into molecular modelling in extremely demanding pharmaceutical industries. The practical aspects of this course involve attending live projects from industries like Supply Chain, Trading, Construction Industry, Sales, Marketing, Finance, and more.
The Highlights
- 1.5 months programme
- 28 hours online course
- Live interactive classes
- Weekend sessions are held
- Industry-endorsed curriculum
- Certificate of completion
Programme Offerings
- 28 Hours Course
- Live Online Course
- Industry Experts Teaching
- Industry Endorsed Curriculum
- Lectures
- Recordings
- Projects
- placement assistance
Courses and Certificate Fees
| Certificate Availability | Certificate Providing Authority |
|---|---|
| yes | edu plus now |
Eligibility Criteria
Educational Qualification
Fresh graduates having 50% marks or even postgraduates including research scholars are eligible.
Work Experience
Some working experience in the industries like bioinformatics, chemical, and biological ones shall be preferred.
Certification Qualifying Details
As the course is fully finished then the Molecular Modelling certification by Indian Statistical Institute, Pune, and eduplusnow will be issued.
What you will learn
The different topics of the Molecular Modelling certification syllabus are tools for molecular modelling, homology, and biology modelling, molecular dynamic simulation, and much more.
Who it is for
See the below list of people who are perfect for getting enrolled:
- New graduates with around 50% or even more marks.
- Anybody with an interest in following molecular modelling.
- Working professionals from the biological and bioinformatics industry may be ideal.
- Research scientists and teachers who have a background of working in biological, chemical and pharmaceutical industries are allowed.
- Ones who are research scholars including both doctoral and postdoctoral ones are eligible.
- Participants with a special interest in knowing what molecular modelling is.
Admission Details
Down below find the Molecular Modelling admission details:
Step 1: Visit the official website: https://www.eduplusnow.com/course-details/molecular-modelling
Step 2: Find the button ‘Enroll Now’ that candidates find on the official site, and click it.
Step 3: After step 2, candidates must record their details to sign up.
Step 4: As sign-up is over, candidates will definitely have to pay the full fee in a go.
Step 5: For secured admission, the fee payment needs to be successful.
The Syllabus
- Theoretical modules
- Basic concepts
- Computational structural biology and homology modelling
- Homology modelling.
- Force field
- Energy minimization and optimization
- Molecular dynamics simulation
- Application of molecular dynamics simulation
- PaDel
- Pymol
- Chimera
- OpenBabel
- Coralsea
- MS Excel
- Gromacs
- Etc.
- Introduction to computational structural biology.
- Importance of molecular structures.
- Useful concepts of molecular modelling.
- Coordinate systems.
- Potential energy surface.
- Concept of quantum mechanics and molecular mechanics.
- Role of molecular modelling in structural optimization.
- Concept of sequence to structure.
- The breadth of Computational Biology
- Emerging Principles in Computational Structural Biology
- Areas that May Take the Center Stage
- Challenges in Computational Structural Biology
- 1. HOMOLOGY MODELLING.
- Target Sequence Selection.
- Template Protein Recognition
- Preparation of Template Protein
- Sequence Alignment
- Prediction of Secondary Structure
- Building Homology Models
- Loop Modeling
- Model Optimization
- Model validation.
- Ramachandran plot | ERRAT | Verify 3D | PROVE | ProCheck | WhatCheck
- Concept of force fields.
- A simple molecular force field.
- General features of molecular mechanics force fields.
- Components of molecular force fields.
- Bonded parameters.
- Bond stretching. | Angle bending. | Torsion angle bending.
- Non-bonded parameters.
- Electrostatic interactions. | Van der Waals interactions.
- Force field parameterization
- The basic concept of different macro-molecular and small molecular force fields.
- Introduction to energy minimization.
- Importance of energy minimization.
- Basic requirements for energy minimization.
- Non-derivative minimization methods
- Simplex method
- Sequential univariate method
- Derivative minimization methods
- Steepest descent algorithm | Conjugate gradients algorithm
- Choice of energy minimization method.
- Concept of different terms.
- Local minima | Global minima | Saddle point
- Introduction of molecular dynamics simulation.
- Role of molecular dynamics simulation in structure optimization.
- Molecular Dynamics Ensembles.
- Preparing system for molecular dynamics.
- Prepare the Protein Topology.
- Prepare the Ligand Topology (For complex).
- Defining the Unit Cell & Adding Solvent.
- Adding Icons.
- Energy Minimization.
- Equilibration. NVT ensemble
- NPT ensemble
- Production molecular dynamics simulation.
- Analysis of molecular dynamics simulation trajectories.
- A real-time example of apoprotein will be considered for at least 10ns molecular dynamics simulation using Gromacs.
- A real-time example of a protein-ligand complex will be considered for at least 10ns molecular dynamics simulation using Gromacs.
- The analysis will be done for both simulation trajectories.
- Backbone root-mean-square deviation
- Ligand- root-mean-square deviation
- Root-mean-square fluctuation of amino acids.
- The radius of gyration.
- Inter-molecular hydrogen bond analysis.
- Extractions of different frames in a certain time intervals.
- Optimization of apoprotein.
- Explore macro-molecule and macro-molecule complex stability in dynamic states.
- Macro-molecule and small-molecule complex stability in dynamic states.
- A real-time example will be considered to generate 3D structure using SwissModeller and/or Modeller.
- Extensive validation and optimization will be done using online validation servers.
Instructors
Indian Statistical Institute, Pune Frequently Asked Questions (FAQ's)
Tools like Chimera, Coralsea, Gromacs, Pymol, are required.
Anyone with less than fifty percent marks is not allowed to participate.
Edu Plus Now is to be found in the state of Maharashtra.
Yes, the course syllabus is in accordance with the recent industry standards.
The callback time falls between 9 am - 9 pm from Monday to Friday.