Yes, you can pursue D.Pharma with your current qualifications, even though you failed physics in your previous studies.

The Pharmacy Council of India (PCI) generally requires candidates to have passed 10+2 (or equivalent) with Science stream subjects like Physics, Chemistry, and Biology for D.Pharma admission.

Failing physics should not necessarily prevent you from applying for D.Pharma. Since you have passed Chemistry and Biology, the core science subjects crucial for D.Pharma, your application might still be considered.

After completing D.Pharma and passing the qualifying exam, you can apply for registration with the PCI. As long as you meet the Pharmacy Act's requirements and have the necessary qualifications, a past failure in physics shouldn't affect your registration.

https://www.careers360.com/pci-full-form

I hope it helps!

No, since you have passed all your subjects, there likely won't be any subject replacement in this scenario. Subject replacement policies typically come into play when a student fails a subject.

You have passed all six subjects, fulfilling the basic requirement to move on to the next grade.
There is no mention of a policy that replaces a subject with the one you scored highest in for promotion to the next class.

https://school.careers360.com/boards/msbshse/maharashtra-state-board-10th-marathi-books-bsar

I hope it helps!