Hi Adi tiwari,
Hope you are doing great as per the question asked by you yes you can score high marks in COMEDK by only studying for ISC but your concept should be very very clear you should have taken all the important topics seriousl. You should have solved some mock papers and previous year questions to get a rough idea of the question paper.
Hope you found this answer useful.Stay motivated stay positive.
All the best!
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