Correct Answer: PLEASE

Solution : Given:
ENCYCLOPEDIA

Now, let's compare all the option words with the word ENCYCLOPEDIA –
First option: OPEN; All the letters of OPEN are present in the word ENCYCLOPEDIA.
Second option: PLEASE; All the letters of PLEASE are not present in the word ENCYCLOPEDIA. S is not present in the word ENCYCLOPEDIA.
Third option: CANOPY; All the letters of CANOPY are present in the word ENCYCLOPEDIA.
Fourth option: PLEAD; All the letters of PLEAD are present in the word ENCYCLOPEDIA.

So, from the above, only PLEASE cannot be formed using the letters of the word ENCYCLOPEDIA. Hence, the second option is correct.