Correct Answer: 2643

Solution : Let's check the given options –
First option: 8465; Divide the number into two halves→84/65; Now, subtract them→84 – 65 = 19
Second option: 2643; Divide the number into two halves→26/43; Now, subtract them→43 – 26 = 17
Third option: 4867; Divide the number into two halves→48/67; Now, subtract them→67 – 48 = 19
Fourth option: 6243; Divide the number into two halves→62/43; Now, subtract them→62 – 43 = 19

So, the second option is different from the other three options as here the difference between the numbers is 17 instead of 19. Hence, the second option is correct.