Correct Answer: REACT

Solution : Given:
LITERATURE

Now, let's compare all the option words with the word LITERATURE –
First option: LITERATE; All the letters of LITERATE are present in the word LITERATURE.
Second option: REAL; All the letters of REAL are present in the word LITERATURE.
Third option: TILE; All the letters of TILE are present in the word LITERATURE.
Fourth option: REACT; The letter C in the word REACT is not present in the word LITERATURE.

So, REACT cannot be formed with the help of the letters of the word LITERATURE. Hence, the fourth option is correct.