Correct Answer: ×, −, =, +, ÷

Solution : Given:
(130 * 4) * 21 * 485 * (28 * 2)

Let's check the options −
First option: +, −, =, −, ×
⇒ (130 + 4) − 21 = 485 − (28 × 2)
L.H.S. = (130 + 4) − 21 = 134 − 21 = 113
R.H.S. = 485 − (28 × 2) = 485 − 56 = 429
L.H.S. ≠ R.H.S.
Second option: ÷, +, =, −, ×
⇒ (130 ÷ 4) + 21 = 485 − (28 × 2)
L.H.S. = (130 ÷ 4) + 21 = 32.5 + 21 = 53.5
R.H.S. = 485 − (28 × 2) = 485 − 56 = 429
L.H.S. ≠ R.H.S.
Third option: ×, −, =, −, ÷
⇒ (130 × 4) − 21 = 485 − (28 ÷ 2)
L.H.S. = (130 × 4) − 21 = 520 − 21 = 499
R.H.S. = 485 − (28 ÷ 2) = 485 − 14 = 471
L.H.S. ≠ R.H.S.
Fourth option: ×, −, =, +, ÷
⇒ (130 × 4) − 21 = 485 + (28 ÷ 2)
L.H.S. = (130 × 4) − 21 = 520 − 21 = 499
R.H.S. = 485 + (28 ÷ 2) = 485 + 14 = 499
L.H.S. = R.H.S.

Hence, the fourth option is correct.