Hello candidate,
Coming onto your first Questions, in order to become a scientist at ISRO you need to have a graduation degree at least with 50% minimum marks from any recognised college and then have to attend the ISRO entrance qualifying examination for further procedures.
The Second question of to select which course in IIST, it pretty much depends on on the score and the rank you have Scored in JEE advanced that whether you are eligible for B-Tech course or for integrated 5 Year Course.
Hope it helps!!
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