Hey Shalini,

The eligibility criteria of ISRO are You must have a minimum of 6.84 CGPA or 65% in your graduation and you can apply for the exam on the final year of exam. There is no mention of 10+2 marks criteria so you can apply for it. But the selection process is based on the academic performance and bio-data, initial screening will be conducted to short-list candidates for the written test.

for more info related to ISRO exam visit https://engineering.careers360.com/articles/isro-recruitment

Hope that helps

all the best