Assuming you are asking for MHTCET and Jee main so you will have to get either 75% in PCM aggregate in 12th or you should be there in top 20 percentile. Also, for MHTCET, C andidates should have passed HSC or its equivalent examination with Physics and Mathematics as compulsory subjects along with one of the Chemistry or Biotechnology or Biology or Technical or Vocational subjects, and obtained at least 50 % marks (at least 45 % marks, in case of Backward class categories and Persons with Disability candidates belonging to Maharashtra State only) in the above subjects taken together.

Hope this helps!!!