Hi Dear,
Yes, you can give GATE exam after studying MSC in Physics. The basic eligibility criteria for gate exam is completion or final semester of Master’s degree in any branch of Science/Mathematics/Statistics/Computer Applications or equivalent. There's no weightage given to 12th score for eligibility criteria of GATE exam.
For more details you can visit the following link:
https://engineering.careers360.com/articles/gate-eligibility-criteria#GATE-Eligibility-Criteria-2021
Good Luck
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