Hello Rohan,
Not difficult! But yes you have to do bit more effort to study biology unless you are having additional biology during your 12th class.
But nothing to worry about, just pay some more attention on biology topics and try to clear to your basic concept.
This will help you to understand biotech subjects more easily.
And if you are going to opt B.Tech biotech, that can be more comfortable for you then B.Sc biotech.
Nothing is so hard that can be never done. So if you seriously want carrier in biotechnology go for it. All the best
Good luck
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