The answer is yes. In fact, many IAS have a science background. As far as eligibility is concerned there is just one requirement of Graduation from any recognized university in any stream. When we talk about prelims is not a big deal in your science or humanities background. Now coming to the Mains there are a lot of choices for optional from science and engineering like Physics, Chemistry, Mechanical Engineering. The one advantage Humanities students have is in the essay and language paper.
But remember hard work and commitments always wins.
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