KLEF University is situated in the census town of Vaddeswaram in Guntur district of Andhra Pradesh. The 100-acre campus is positioned at the banks of Buckingham Canal, eight kilometres from Vijayawada city. The closest railway station from KL University Guntur campus is Kolanukonda Railway Station, nearly 2.4 km away. The nearest airport is in Vijayawada, around 27.8 km from the institute. The university also runs bus services for students to travel to significant nearby destinations.  KLEF University also has a new off-campus in Hyderabad, Telangana.