Correct Answer: Sacrilege

Solution : The fourth option is correct.

The most appropriate one-word substitution for the violation or profanation of anything sacred or held sacred will be sacrilege.

Sacrilege: It refers to the violation or misuse of what is regarded as sacred.

The meanings of the other words are:

Pious: It is an adjective that describes a deep religious devotion or reverence, often associated with a sincere and earnest commitment to religious principles and practices.

Sacramentals: These are sacred signs and symbols used in religious practices that are believed to convey spiritual blessings or grace.

Holy: It is often used to describe things that are dedicated or set apart for religious purposes and are considered to be spiritually significant.