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The pyrimidine nucleobase Uracil is found only in A. DNA B. RNA C. Both in DNA & RNA D. PNA


Rudra Narayan Patra 18th Feb, 2019
Answer (1)
Abhijit_1514089823 Student Expert 19th Feb, 2019

Hi Rudra Narayan Patra !

Uracil is one of the four nucleobases in the nucleic acid of RNA. Uracil's use in the body is to help carry out the synthesis of many enzymes necessary for cell function through bonding with riboses and phosphates. Uracil serves as allosteric regulator and coenzyme for reactions in animals and in plants. UMP controls the activity of carbamoyl phosphate synthetase and aspartate transcarbamoylase in plants, while UDP and UTP requlate CPSase II activity in animals . UDP-glucose regulates the conversion of glucose to galactose in the liver and other tissues in the process of carbohydrate metabolism . Uracil is also involved in the biosynthesis of polysaccharides and the transportation of sugars containing aldehydes .Uracil is important for the detoxification of many carcinogens, for instance those found in tobacco smoke.Uracil is also required to detoxify many drugs such as cannabinoids (THC) and morphine (opioids). It can also slightly increase the risk for cancer in unusual cases in which the body is extremely deficient in folate . The deficiency in folate leads to increased ratio of deoxyuracilmonophosphates (dUMP)/ deoxythyminemonophosphates (dTMP) and uracil misincorporation into DNA and eventually low production of DNA.

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