What are the different types of Inhibition ?
Hi Tamoghna,
Inhibition of specific enzymes by drugs are useful for medicine.Mechanism of enzyme is an important part to study. There are four types of enzyme inhibition – competitive, non- competitive, uncompetitive, and suicide. Of these, the first three types are reversible and the last one is irreversible.
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I hope this information helps you.
Good Luck!
Hello Student,
I guess you are talking about Inhibition of Enzymes
Different Types of Inhibition :
- Competitive - Competitor resembles substrate and binds to active site
Km value increases but Vmax remains same
E.g : Malonate inhibits succinate dehydrogenase, Sulpha drugs inhibit folic acid synthase
- Non-Competitive - Competitor binds to sites other than the active site
Km remains same but Vmax decreases
E.g - Cytochrome oxidase inhibition by cyanide ions
- Allosteric or Feedback Inhibition - Competitor binds to a site other than the active site which results in modulation of the active site.
E.g - Inhibition of Threonine Deaminase by Isoleucine, Inhibition of Phosphofructokinase by ATP, Inhibition of Hexokinase by Glucose-6-Phosphate.
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