Hrisheekesh Singh 4th Apr, 2020

Hi Tamoghna,

Inhibition of specific enzymes by drugs are useful for medicine.Mechanism of enzyme is an important part to study. There are four types of enzyme inhibition – competitive, non- competitive, uncompetitive, and suicide. Of these, the first three types are reversible and the last one is irreversible.

Feel free to ask doubts in the Comment Section.

I hope this information helps you.

Good Luck!

Pratyay Islam 4th Apr, 2020

Hello Student,

I guess you are talking about Inhibition of Enzymes

Different Types of Inhibition :

• Competitive - Competitor resembles substrate and binds to active site

Km value increases but Vmax remains same

E.g : Malonate inhibits succinate dehydrogenase, Sulpha drugs inhibit folic acid synthase

• Non-Competitive - Competitor binds to sites other than the active site

Km remains same but Vmax decreases

E.g - Cytochrome oxidase inhibition by cyanide ions

• Allosteric or Feedback Inhibition - Competitor binds to a site other than the active site which results in modulation of the active site.

E.g - Inhibition of Threonine Deaminase by Isoleucine, Inhibition of Phosphofructokinase by ATP, Inhibition of Hexokinase by Glucose-6-Phosphate.