What happens in Histotoxic Hypoxia ?
Answer (1)
7th Apr, 2020
Hello ,
Here is all that you need to know about Histotoxic Hypoxia :
- Occurs due to blockage of cellular enzymes that utilize oxygen
- Commonly happens in cyanide poisoning
- Cyanide inhibits cytochrome oxidase enzyme in mitochondria leading to blockage of oxidative phosphorylation
- Alveolar PO2 and Arterial PO2 and oxygen content may be normal
- Tissue can't utilize oxygen, Venous PO2 and oxygen content are elevated
- Arteriovenous O2 difference is reduced
- Oxygen therapy is not helpful
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