Hi Aradhna,
The Department of Pre-University Education is the state government education board of Karnataka (PUC board). And CBSE (Central board for secondary education) is a nation level board. PUC board has comparatively easy syllabus than CBSE syllabus and only focuses on core subjects. So, if you are from karnataka, you can choose PUC board, as state board exam scores are valid all over India.
Thankyou!
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