Characteristics of tight junctions ?
Answer (1)
7th Apr, 2020
Hello ,
Characteristics of Tight Junctions :
- These are also known as zona occludens
- Play major role in maintaining epidermal barrier permeability by regulating the paracellular flux of water soluble molecules between adjacent cells
- They help in formation of blood brain barrier.
- Major tight junction proteins are Claudins and Occludins
- Tight junctions are responsible for resorption of magnesium ion from thick ascending loop of henle
- Mutation in tight junction protein claudin leads to familial hypomagnesemia with hypercalciuria and nephrocalcinosis.
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