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yes, it is possible to study management after biotechnology despite them being absolutely different. you will have an edge over the other candidates for placement of managerial posts in biotech and pharmaceutical firms.
Talking about the difficulty, it depends on the specialisation in MBA that you wish to do.Also you may face difficulty in auditing,accounting and economics but little extra effort will help you overcome that problem.
suitable specialisations for you- HR, sales, marketing, supply chain management
Remember there is nothing that a science student cannot do.
cheers!
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