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The main difference between plasmid DNA and chromosomal DNA is that the plasmid DNA only contains additional genes not useful for the survival of the organism whereas chromosomal DNA contains all the necessary information for the growth, development, and reproduction of the organism. Plasmid DNA and chromosomal DNA are two types of DNA mainly found inside living cells. Both encode for the genes. Furthermore, plasmid DNA is a type of extrachromosomal DNA and is not a type of genomic DNA. In fact, only chromosomal DNA is considered as genomic DNA.
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