Sir I belongs to sc category and my state of origin is Karnataka , as my grandparents were migrated from Karnataka to Maharashtra we can't aquire or get any reservations benefit of sc category in Maharashtra.
So If  I want to get reservations benefit then it will get only in Karnataka state .
And In Karnataka there is our house and land which belongs to our grandparents.
If I cancelled my domacile certificate of Maharashtra , can I get Karnataka domacile for educational purposes and to get reservations benefit.

Then you need to search more about it as you said that you're born in Karnataka then there are chances of you getting the domicile. You must search about it on the government sites related to domicile. 

Thanks
But I born in Maharashtra. My father born in Karnataka.
I possess now the sc cast certificate of Karnataka government.
Have any chance to get domacile certificate from Karnataka.

But if you're born and brought up in Maharashtra then you're by default a domicile of Maharashtra state. 

So there is no any way to get state benefit of Karnataka ?